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| Rodríguez,Esteban M; Guerra,María M; Vío,Karin; González,César; Ortloff,Alexander; Bátiz,Luis F; Rodríguez,Sara; Jara,María C; Muñoz,Rosa I; Ortega,Eduardo; Jaque,Jaime; Guerra,Francisco; Sival,Deborah A; Dunnen,Wilfred F. A. den; Jiménez,Antonio J; Domínguez-Pinos,María D; Pérez-Fígares,José M; McAllister,James P; Johanson,Conrad. |
| Most cells of the developing mammalian brain derive from the ventricular (VZ) and the subventricular (SVZ) zones. The VZ is formed by the multipotent radial glia/neural stem cells (NSCs) while the SVZ harbors the rapidly proliferative neural precursor cells (NPCs). Evidence from human and animal models indicates that the common history of hydrocephalus and brain maldevelopment starts early in embryonic life with disruption of the VZ and SVZ. We propose that a "cell junction pathology" involving adherent and gap junctions is a final common outcome of a wide range of gene mutations resulting in proteins abnormally expressed by the VZ cells undergoing disruption. Disruption of the VZ during fetal development implies the loss of NSCs whereas VZ disruption... |
| Tipo: Journal article |
Palavras-chave: Hydrocephalus; Abnormal neurogenesis; Neural stem cells; Stem cell transplantation. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300005 |
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| Selle,F.; Gligorov,J.; Richard,S.; Khalil,A.; Alexandre,I.; Avenin,D.; Provent,S.; Soares,D.G.; Lotz,J.P.. |
| Germ cell tumors present contrasting biological and molecular features compared to many solid tumors, which may partially explain their unusual sensitivity to chemotherapy. Reduced DNA repair capacity and enhanced induction of apoptosis appear to be key factors in the sensitivity of germ cell tumors to cisplatin. Despite substantial cure rates, some patients relapse and subsequently die of their disease. Intensive doses of chemotherapy are used to counter mechanisms of drug resistance. So far, high-dose chemotherapy with hematopoietic stem cell support for solid tumors is used only in the setting of testicular germ cell tumors. In that indication, high-dose chemotherapy is given as the first or late salvage treatment for patients with either relapsed or... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High-dose chemotherapy; Germ cell tumors; Stem cell transplantation; Solid tumors; Breast cancer; Ovarian cancer. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100013 |
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